PCM @ Tylenol

-

Myth of Paracetamol


Seen by a pediatric patient's mother today. Worried and anxious, she asked regarding the dose and myth of Paracetamol before giving it to her child. 
 

" Legends says that, when Paracetamol is taken, it will remain in the body until the day one dies. "


*Staring at her in disbelief*  (  O_O)


This is what was told by her, with a concern that her newborn child will have to bear the Paracetamol in its body until the day it passes away.


Sounds funny and unbelievable, but this is what happens right now in reality due to misinformation.


Paracetamol (PCM) @ Panadol®, also known as Acetaminophen (AAP) @ Tylenol® in some regions, especially in the US, is a wonderful drug. It is can be found worldwide in different brands and strength.


PCM can be used as either mild analgesic or antipyretic for treating fever. However, how it actually works is still a mystery itself. 


Some debate that it works through prostaglandin synthesis inhibition, whereas some say that it interacts with cannabinoid receptors located in the brain.


So, how to determine the dose for PCM through weight-based dosing?


It's very simple. 


For pediatrics, Ideal Body Weight or Actual Body Weight can be used, whichever is lower:
15mg/kg per dose with a maximum of 60mg/kg daily dose.

i.e. Weight = 12kg         Age = 3 years old

Ideal body weight (IBW) = 15kg

Amount of PCM per dose = 180mg

Maximum daily dose = 720mg

For Adults, one should be counseled that PCM should not be taken more than 4g per day (i.e. total of 8 x 500mg tablets in divided doses such as 1000mg four times daily)


To answer regarding the myth about PCM remains lifelong in the body. We must first understand one thing. 

What is a half-life?



A half-life is the time taken for a particular drug to have its original concentration by halves.


To estimate whether a drug has been eliminated from our body, it usually takes around 4 to 5 half-lives.


PCM has a half life of approximately 2 hours. Theoretically, it will be left in negligible amount within our body after a day. 

In short, it is safe to take PCM as long as the maximum dose is not exceeded.

Popular Posts

Ways To Boost Fertility In Men

-
Ways To Boost Fertility in Men Reducing stress, active in exercising, a change to daily diet and lifestyle can help to boost fertility. Infertility is a more common issue than you might think. Fret not, fertility can be boosted through simple changes in diet, lifestyle or supplementation. Today we will discuss about what we can consume to boost fertility in male. 1. Zinc Zinc - a very common metal element in the periodic table, is also one of the elements that plays a crucial role in male's fertility. It is used as an indispensable component in testosterone. Zinc deficiency in men can lead to reduction in sex drive, low sperm motility and low sperm count, which in turns, contributing to male infertility. Daily recommendation for zinc intake is 25mg. Make sure to get enough from your diet and supplements! Daily recommendation: 25mg/day 2. Vitamin D The expression of Vitamin D receptors and metabolizing enzyme in testis and sperms has been suggested since long ago. A lack...
Read more

Osteoarthritis? Looking into Collagen Type II

-
Osteoarthritis? Looking into  Type II Collagen Collagen is one of the components made up of cartillage, bone and connective tissues in human body. Collagen exists in many different forms. There are at least 16 different types of collagen. The more commonly known ones are the Type I and II collagens . Type I collagen is densely packed and is used in structural components of skin, bones, tendons and ligaments, whereas Type II collagen is usually found in cartillage, joints and connective tissues, giving them structural strength and elasticity. Type II collagen is abundant in chicken cartillage and bones. It can be naturally obtained through consuming chicken bone broth.  So, how does Type II Collagen helps with osteoarthritis?   Type II Collagen contains high amount of glucosamine sulfate and chondroitin sulfate which helps to promote cartillage growth. Consuming Type II Collagen helps to improve joint comfort and flexibility. Other than that, Type II Collagen also helps wi...
Read more

Intro to N-O-D

-
About Us Just your regular legal drug-dealers stationed in Malaysia blogging about daily life.  ; ) New to blogging world. Feel free to drop some comments below.
Read more

Knee hurt ? Joint pain ? Pain and Inflammation - Narcocin by Brego

-
Knee hurt ? Joint pain ? Pain and Inflammation - Narcocin by Brego™ Narcocin contains anti-inflammatory molecules that helps to alleviate pain and improve joint mobility. Today we'll provide a little bit of sharing regarding this product Narcocin  that we have came across few times in local pharmacies. Narcocin Looking at its aethetic packaging, it seems legit like something non-related to pain relief. After examining the ingredients and did some research on them, we found that Narcocin  is quite a unique product. Narcocin itself contains Univestin , a mixture blend of Chinese skullcap (黄芩) @ Scutellaria Baicalensis and   Heartwood Acacia catechu in the strength of 250mg extract. Pain and Inflammed - The benefits of Univestin Both the ingredients of Univestin  has long been used in oriental traditional remedies for pain. A combination of both boost the anti-inflammatory property even more! Studies has shown that combination of Scutellaria b...
Read more