Intravenous Infusion Calculation

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Intravenous Infusion


Today we'll be sharing on intravenous (IV) infusion calculation.


Many medications can be given via IV infusion route for inpatient care. A few commonly used examples are Noradrenaline, Adrenaline, Labetalol, Glyceryl trinitrate.


Calculation on IV infusion medications can sometimes leaving one in confusion while figuring out how many vials or ampoules are required, especially for pharmacist who is new to inpatient care like PRP.




So, to get your hands on practice, let's start with a few examples.

Example 1: 
Today, Dr M ordered IV Glyceryl Trinitrate (GTN) 5mcg/min for 5 hours. 
What is the infusion rate?
How much ampoule do we need?
IV GTN available strength: 50mg/10ml
Dilution method: Dilute 50mg in 500ml diluent
1.1 First determine the dose required:
Dose (mg/hr)
= Dose (mcg/min) x 60 min/hr ÷ 1000 mcg/mg
= 5 x 60 ÷ 1000
= 0.3 mg/hr

1.2 Determine the concentration that we have:
Concentration (mg/ml)
= 50mg ÷ 500ml
= 0.1 mg/ml

1.3 Infusion rate
Rate (ml/hr)
= Dose (mg/hr) ÷ Concentration (mg/ml)
= 0.3 mg/hr / 0.1 mg/ml
= 3ml/hr

1.4 Ampoules required
Total amount of drug required
= Dose (mg/hr) x Duration of infusion (hr)
= 0.3 mg/hr x 5 hr 
= 1.5mg 
• 1 ampoule is supplied as 1 ampoule contains 50mg of GTN


Example 2:
Dr J ordered double con IV Noradrenaline to run over 24 hours at 3ml/hours.
How many ampoules do we need?
IV Noradrenaline available strength: 4mg/4ml
Dilution method: Dilute 8mg in 50ml diluent

1.1 Determine dose required
Dose 
= 8mg / 50ml x 3 ml/hr x 24 hrs
= 11.52mg
*8mg (2 ampoules of 4mg) is used as Double Con is indicated

1.2 Determine amount of ampoule needed
Ampoule needed
= Total Dose Required ÷ Strength per Ampoule
=11.52mg ÷ 4mg
=2.88
• 3 ampoules are needed but 4 ampoules are supplied as we have to bear in mind that double con requires 2 ampoules per dilution.



It is of the utmost importance for a pharmacist to have his/her calculations at fingertips, and bear in mind to be quick, precise and most importantly accurate!
The calculation for infusion can be tricky at first, but do not fret. Keep calm and overcome it.


             Per aspera 
                               ad astra






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